2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2879
    Cholesterol esterase, Pseudomonas 9026-00-0
    Cholesterol esterase, Pseudomonas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption.
    Cholesterol esterase, Pseudomonas
  • HY-P3651
    Cholecystokinin (26-33) (free acid) 103974-46-5 99.82%
    Cholecystokinin (26-33) (CCK (26-33)) free acid is a cholecystokinin (CCK) fragment. Cholecystokinin (26-33) free acid can reduce food intake and gallbladder contraction.
    Cholecystokinin (26-33) (free acid)
  • HY-P4385
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) 129622-68-0 99.32%
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist.
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
  • HY-P4633
    γ-Glu-Tyr 7432-23-7 98.35%
    γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC50=6.77 mM), is a potentially functional component of the type 2 diabetes diet.
    γ-Glu-Tyr
  • HY-Y1819
    2-Acetonaphthone 93-08-3 99.89%
    2-Acetonaphthone is an endogenous metabolite.
    2-Acetonaphthone
  • HY-101293
    VU0359595 1246303-14-9 98.06%
    VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
    VU0359595
  • HY-101336
    RS 17053 hydrochloride 169505-93-5 99.93%
    RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
    RS 17053 hydrochloride
  • HY-104051
    Monacolin J 79952-42-4 99.22%
    Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
    Monacolin J
  • HY-107825
    Flavonol 577-85-5 ≥98.0%
    Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases.
    Flavonol
  • HY-108753
    Eteplirsen 1173755-55-9
    Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. Eteplirsen can be used for Duchenne muscular dystrophy research.
    Eteplirsen
  • HY-113082
    L-Thyronine 1596-67-4 98.91%
    L-Thyronine is a deiodinated thyroxine.
    L-Thyronine
  • HY-113284
    Succinyladenosine 4542-23-8 ≥98.0%
    Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency.
    Succinyladenosine
  • HY-113435
    8-Dehydrocholesterol 70741-38-7
    8-Dehydrocholesterol elevated concentration is one of the diagnostic biochemical hallmarks of classical Smith-Lemli-Opitz syndrome (SLOS).
    8-Dehydrocholesterol
  • HY-114011
    AMG7703 1103523-24-5 99.24%
    AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.
    AMG7703
  • HY-117095
    4-Methylumbelliferyl oleate 18323-58-5 ≥98.0%
    4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm).
    4-Methylumbelliferyl oleate
  • HY-117391
    AZ-Dyrk1B-33 1679330-37-0 ≥99.0%
    AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM.
    AZ-Dyrk1B-33
  • HY-119506
    KL044 1801856-93-8 99.05%
    KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.
    KL044
  • HY-123046
    AS1708727 1253226-93-5 99.44%
    AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.
    AS1708727
  • HY-123984
    LTβR-IN-1 2189366-77-4 99.79%
    LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner.
    LTβR-IN-1
  • HY-124265
    4β-Hydroxycholesterol 17320-10-4 ≥98.0%
    4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.
    4β-Hydroxycholesterol
Cat. No. Product Name / Synonyms Application Reactivity